Vilitra 40 mg, which contains vardenafil as its active ingredient, is metabolized primarily in the liver. The process involves the cytochrome P450 enzyme system, especially the CYP3A4 isoenzyme, with minor contributions from CYP3A5 and CYP2C9. After oral administration, vardenafil is absorbed into the bloodstream and undergoes first-pass metabolism in the liver, which significantly reduces its bioavailability. The metabolites produced are largely inactive or less active than the parent compound. These metabolites are then excreted primarily through the feces, with a smaller portion eliminated in the urine. The metabolism and elimination of Vilitra 40 are influenced by age, liver function, and potential drug interactions.
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